Cell-cell communication in Gram-negative bacteria.

نویسندگان

  • Martin Welch
  • Helga Mikkelsen
  • Jane E Swatton
  • Debra Smith
  • Gemma L Thomas
  • Freija G Glansdorp
  • David R Spring
چکیده

Over the last decade or so, a wealth of research has established that bacteria communicate with one another using small molecules. These signals enable the individuals in a population to coordinate their behaviour. In the case of pathogens, this behaviour may include decisions such as when to attack a host organism or form a biofilm. Consequently, such signalling systems are excellent targets for the development of new antibacterial therapies. In this review, we assess how Gram-negative bacteria use small molecules for cell-cell communication, and discuss the main approaches that have been developed to interfere with it.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Petra, osiris and molinspiration: A computational bioinformatic platform for experimental in vitro antibacterial activity of annulated uracil derivatives

Annulated pyrano[2,3-d]pyrimidine/pyrano[2,3-d]uracil derivatives were synthesized using aromatic aldehydes, active methylene compounds and barbituric acid in presence of dibutylamine (DBA) catalyst in ethanol as solvent. The different substituents on phenyl ring in the fused pyrano uracil skeleton showed productive influence on its antimicrobial activity against some gram positive and gram neg...

متن کامل

Antagonistic activity of Streptomyces gresiofuscus PTCC1628 against isolated Gram negative bacteria from Urinary Tract Infections

  Antibiotics are the best known products of actinomycete. Over 5,000 antibiotics have been identified from the cultures of Gram positive and Gram-negative organisms, and filamentous fungi, but only about 100 antibiotics have commercially been used to treat human, animal and plant diseases. The genus, Streptomycete, is responsible for the formation of more than 60% of known antibiotics. Bacteri...

متن کامل

مقایسه تاثیر گیاه همیشه‌بهار با سفالوسپورین‌ها بر باکتری‌های جدا شده از بیماران مبتلا به سلولیت

Abstract Background: Presence of the beta-lactamase enzyme results in microbial resistance to beta-lactam and cell wall synthesis inhibitor antibiotics. This study was conducted to compare effects of Calendula officinalis extract and cephalosporines, as a cell wall synthesis inhibitor antibiotic, on bacteria isolated from patients with cellulitis. Methods: This experimental study was done o...

متن کامل

Comparing Invasive and Non-Invasive of Isolated Shigella flexneri by Electron Microscopy of Cell Culture, SDS-PAGE and Congo Red Method

The aim of this study was to compare invasive and non-invasive strains of Shigella flexneri isolated from Tehran by a 120 kDa protein band by SDS-PAGE, electron microscopy of cell culture and Congo red dye methods. Methods: S. flexneri strains were isolated by standard bacterial methods from fecal specimens of children attending to the 3 children’s hospitals. Phenotype analysis for screening v...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Molecular bioSystems

دوره 1 3  شماره 

صفحات  -

تاریخ انتشار 2005